One of the key indicators tracking institutional interest in the cryptocurrency market, the Coinbase premium, slid further into negative territory in May. Since this metric closely reflects the demand for Bitcoin from large US-based investors, it remains a focal point for market watchers monitoring broader trends.
Coinbase premium sees sharp decline
The Coinbase premium measures the price difference for Bitcoin between the major US exchange Coinbase and global heavyweight Binance. Typically, institutional investors in the US favor Coinbase, while individual investors tend to use Binance. On May 21, the premium fell to -0.0983%, its lowest level for the month. CryptoQuant analyst Darkfost highlighted that institutional selling has intensified in recent weeks.
Darkfost noted that institutional selling pressure has recently picked up speed again and pushed the indicator deep into negative territory.
Similarly, during this period, demand for Bitcoin on US spot markets has remained weak, with the price premium hovering in the negative. Analyst Axel Adler explained that current price movements indicate there is yet to be confirmation of renewed spot demand coming from the US.
Glossary: The Coinbase premium refers to the price gap for Bitcoin between US-based Coinbase and global exchange Binance. A positive premium signals US demand, while a negative figure points to institutional selling pressure.
Macroeconomic uncertainty influences investor behavior
In line with the pressure across crypto markets, institutions have also been steering clear of other popular refuges. Gold prices have dropped by 5.8% in the past month, while major US indices such as the S&P500 and Dow Jones have been trending up since early April. Observers suggest that risk appetite among investors is shifting toward equities. Analysts also argue that ongoing global economic uncertainties have further fueled risk aversion, particularly in crypto assets.
According to CryptoQuant’s analysis, institutional investors appear to be holding off on initiating new positions, instead adopting hedge strategies to manage short-term risks in the current landscape.
Spot Bitcoin ETF outflows and futures market shifts
Another clear sign of institutional selling has come from outflows in US-based spot Bitcoin ETFs. Data from CoinGlass shows that over four trading days since May 14, spot Bitcoin ETFs saw a total outflow of $1.3 billion, signaling that large portfolios are in risk-reduction mode.
In parallel, open interest in Bitcoin futures dropped by $1.5 billion this week. According to analysts, most of the leverage built up during Bitcoin’s rapid rally has now been unwound. Bitfinex further observed that short positions have declined, while long positions have been revised downward, suggesting that upcoming price moves will hinge more on spot market demand.
| Before May 14 | May 14–21 period | |
|---|---|---|
| Coinbase premium | Around -0.05% (average) | -0.0983% (monthly low) |
| Spot Bitcoin ETF outflow | Stable | $1.3 billion outflow |
| Futures open interest | High leverage | Down $1.5 billion |
| Bitcoin price | Near $82,000 | Tested $76,000 level |
Latest on Bitcoin price movements
All these developments have left a mark on Bitcoin’s price action. Over the past week, BTC lost 4.5%, briefly dipping to around $76,000 on May 21, its lowest point of the month. At the time of reporting, Bitcoin was moving sideways at $77,621. Since its peak in October, BTC has shed 38% of its value.




